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Dernière mise à jour : Mai 2018

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Understanding the development and control of stability in the rumen microbiome as a basis for new strategies to reduce methanogenesis

Richard Dewhurst (coordinator)

RumenStability

The project will identify and exploit long-term effects of short-duration dietary treatments on methane production, rumen function and responses to methane mitigation interventions at a later stage. There will be a focus on manipulations in early life, when the rumen community is developing, but also work on other diet transitions. The idea is to reduce the cost and effort of mitigation strategies by reducing the duration and/or quantity of treatment required and/or to increase the size of responses if treatments have to be reapplied. Whilst earlier studies with young ruminants have used potent anti-methanogenic compounds, this work focuses on the residual effects of some of the dramatic diet transitions experienced on-farm, including weaning and transitions to grazing or high-density finishing diets. This project addresses effects of management history on the interaction between the host and its microbiome and on methane production. The ability to identify differences between animals makes the work highly complementary to existing programs on the effects of host genetics/genomics on methane production. We will build on recent work showing residual anti-methanogenic effects of bromochloromethane administered to goat kids. Our primary hypothesis is that the initial microbial implantation in the rumen influences the microbial ecosystem later in life. One aspect of this is transfer of the maternal microbiome to offspring, which may contribute to stability of the rumen microbiome in later life (e.g. reversion to the original community after rumen swapping). We will extend the work on stability of the rumen microbiome to important diet transitions in growing/adult animals. We will use state-of-the-art immunology to test our second hypothesis, that differences in the rumen microbiome in early life affect the development of the host immune response to the microbiome. We will use a combination of the most current and cost-effective techniques to profile the short- and long-term responses of the rumen microbiome diversity and activity, focusing analysis where treatments have shown a clear effect on methane production. We will also address the need for biomarkers for the establishment of methanogenesis using both targeted (archaeol) and non-targeted metabolomics with faeces, rumen fluid, urine and blood. There are five components to the work:
1. New animal studies – investigating long-term effects of previous dietary treatments or anti-methanogenic additives on methane production. These will include studies around weaning, as well as in adult life - with commercially relevant treatments;
2. Additional analysis of samples from new/existing studies to help interpret responses. These may be run by the partner conducting the study or facilitated through exchange of samples.
3. Workshops and short-term visits for training in new methods and standardisation of methodology.
4. Evaluation of the economic viability of strategies identified in the project.
5. Dissemination of results and recommendations to stake-holders and policy makers.